Kentucky Opens as Slight Favorite Over Santa Clara

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Kentucky opened as a 2.5-point favorite over Santa Clara shortly after the NCAA Tournament bracket was announced.

Kentucky opens as a 2.5 point favorite in the first round game vs Santa Clara on @DKSportsbook pic.twitter.com/DKRIoOSAxy

— Drew Franklin (@DrewFranklinKSR) March 15, 2026

FanDuel has the Cats favored by 3.5 points:

The game will tip off at 1:40 p.m. ET on Friday. The game will air live on TNT.